Radiotheranostic Agents Targeting Neuroblastoma: State-of-the-Art and Emerging Perspectives

نویسندگان

چکیده

Neuroblastoma (NB) represents the most common extracranial tumor of childhood. Prognosis is quite variable, ranging from spontaneous regression to aggressive behavior with wide metastatization, high mortality, and limited therapeutic options. Radiotheranostics combines a radiopharmaceutical pair in unique approach, suitable both for diagnosis therapy. For many years, metaiodobenzylguanidine (MIBG), labeled 123I imaging or 131I therapy, has represented main theranostic agent NB, since up 90% NB incorporates aforementioned radiopharmaceutical. In recent novel agents hold promise moving field radiotheranostics forward. particular, SarTATE, consisting octreotate targeting somatostatin receptors, been applied encouraging results, 64Cu-SARTATE being used disease detection 67Cu-SARTATE Furthermore, evidence highlighted potential targeted alpha therapy (TAT) treating cancer by virtue particles’ ionizing density probability killing cells along their track. On this path, 211At-astatobenzylguanidine (MABG) developed as TAT actually under evaluation preclinical models. review, we performed web-based desktop literature research concerning radiotheranostic approaches covering radiopharmaceuticals already implemented clinical practice (i.e.,123/1311-MIBG) those still preliminary phase.

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ژورنال

عنوان ژورنال: Onco

سال: 2021

ISSN: ['2673-7523']

DOI: https://doi.org/10.3390/onco1020011